Course Overview

Accurate analytical measurements are vital in the oil and gas industry to ensure product quality, regulatory compliance, and efficient operations. Gas and liquid chromatography are widely used analytical techniques for identifying and quantifying complex chemical compounds across exploration, production, refining, and laboratory environments.

The Gas and Liquid Chromatography and Troubleshooting programme by Transformentors Academy provides participants with a practical understanding of chromatographic principles, instrumentation, and laboratory best practices. The course covers the operation of gas and liquid chromatography systems, sample preparation, method optimisation, and data interpretation to achieve accurate and reliable analytical results.

Through practical applications and troubleshooting exercises, participants will develop the skills to diagnose common system issues, optimise analytical methods, and improve laboratory performance while maintaining high standards of quality, accuracy, and operational efficiency.

Agenda

Day — 1 Chromatography Fundamentals

• Understanding the principles of chromatography in analytical laboratory applications
• Exploring separation mechanisms in chromatographic systems
• Reviewing key chromatographic parameters affecting separation quality
• Examining factors influencing peak behaviour and analytical performance
• Understanding detector fundamentals in chromatographic measurements
• Applying sample preparation techniques for reliable analytical results
• Case Study: Identify the causes of distorted peaks resulting from sample preparation issues

Day — 2 Gas Chromatography (GC) Systems and Operation

• Understanding gas chromatography systems and the analytical workflow
• Exploring carrier gas selection and its impact on GC performance
• Examining injection techniques used in gas chromatography analysis
• Reviewing GC inlet systems and maintenance best practices
• Identifying column types and their role in chromatographic separation
• Exploring detector options for gas chromatography applications
• Case Study: Diagnose retention time drift and peak anomalies in a GC system

Day — 3 Liquid Chromatography (HPLC and UPLC) Systems

• Understanding liquid chromatography systems and their operating principles
• Exploring pump and injection systems in liquid chromatography workflows
• Reviewing column types used in HPLC and UPLC applications
• Identifying mobile phase selection strategies for optimal separation
• Exploring detector types used in liquid chromatography analysis
• Examining elution techniques in chromatographic separation processes
• Case Study: Identify the causes of poor separation resulting from incorrect mobile phase selection

Day — 4 Method Development, Validation and Quality Control

• Understanding approaches to method development in chromatographic analysis
• Identifying analytical objectives for fit-for-purpose method design
• Selecting appropriate columns and detectors for analytical methods
• Exploring data acquisition and processing in chromatographic systems
• Applying optimisation strategies to improve separation performance
• Understanding calibration and linearity in analytical measurements
• Case Study: Evaluate method validation results and identify potential analytical issues

Day — 5 Troubleshooting and Optimisation in Chromatography

• Applying troubleshooting techniques to chromatographic systems in laboratory environments
• Exploring root cause analysis methods for analytical problems
• Reviewing system suitability tests in chromatographic quality control
• Understanding quality standards and best practices in laboratory operations
• Identifying the causes of poor resolution and retention time shifts
• Examining common peak issues and their impact on analytical results
• Case Study: Diagnose peak shape issues and recommend corrective actions
• Course Review: Key takeaways and programme evaluation

Learning Outcomes

By the end of the Gas and Liquid Chromatography and Troubleshooting course, participants will be able to:

• Understand the fundamental principles of gas and liquid chromatography and their industrial applications.
• Compare gas and liquid chromatography techniques to select appropriate analytical methods.
• Apply best practices throughout the analytical workflow to ensure accurate and reliable results.
• Analyse chromatographic performance to improve method efficiency and laboratory productivity.
• Operate and maintain chromatographic systems to support long-term instrument reliability.
• Evaluate analytical methods against quality assurance and regulatory requirements.
• Diagnose and troubleshoot common chromatographic issues using structured problem-solving techniques.

Who Should Attend

This programme is ideal for:

• Laboratory analysts and technicians
• Chemists and quality control specialists
• Research and development professionals
• Technical staff working in analytical laboratories
• Professionals involved in testing, measurement, and quality assurance
• Anyone seeking to enhance their expertise in chromatographic analysis and troubleshooting